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214697-26-4 - RQCXKDWOCUJWQZ-UHFFFAOYSA-N - ABT 702 - Similar structures search, synonyms, formulas, resource links, and other chemical information.

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ABT-702 dihydrochloride is a potent adenosine kinase (AK) inhibitor. Targets&IC50: Adenosine kinase :ic50 1.7nM, Animal Research: Rats are fasted for 16 hours prior to use. At the beginning of the experiment, each rat is weighed, and then ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy. N. Elsherbiny, Saif Ahmad, +6 authors G. Liou; Life sciences; 2013; Corpus ID: 34162143. AIMS This study was undertaken to determine the effect of an adenosine kinase inhibitor (AKI) in diabetic retinopathy (DR). We Vulcanchem offers qualified products for CAS No. 1188890-28-9(ABT 702 Dihydrochloride), please inquire us for more detail.

Kinetic studies revealed that AK inhibition by ABT-702 was competitive with respect to ADO and noncompetitive with respect to MgATP(2-). ABT-702 increases extracellular adenosine levels in the isolated spinal cord of neonatal rats (Takahashi et al., 2010). Accordingly, ABT-702 may affect neuronal activities of nociceptive pathways in the spinal cord.

ABT‐702 significantly reduced the postdischarge (10 mg kg −1, P=0.0001), and C‐fibre evoked responses (10 mg kg −1, P=0.0001) of spinal neurones in SNL rats (Figure 3A,B). In sham operated rats, however, the postdischarge was facilitated following the administration of ABT‐702.

Beclabuvir(BMS-791325). Lomibuvir. ABT-702.

Effects of ABT-702 treatment on cardiac and vascular parameters in lean and obese ZSF1 rats.A, Representative echocardiogram images of lean and obese ZSF1 rats treated with ABT-702 or vehicle, at 24 wk of age, before the treatment switch.

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av E Byfeldt · 2017 — gentemot beställaren när AB/ABT inte inkorporerats i kontraktet .
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Köp. AL880 Köp. AL702 · AL HURUF ALHIJAYIAT (bokstavsöving och ordövning), 15 kr. Även för detta finns regleringar i AB 04 och ABT 06, bland annat om protokoll från möten och entreprenörens skyldighet att föra dagbok över 031-702 14 03. E-post I AB 04 kap 5 § 22 och i ABT 06 kap 5 § 23 föreskrivs att entreprenören ska ha allriskförsäkring och ansvarsförsäkring.

Description: ABT 702 Dihydrochloride is a potent non-nucleoside adenosine kinase inhibitor, selective over other sites of adenosine interaction like A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase. It displays oral activity in animal models of pain and inflammation.
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The involvement of adenosine signaling in the anti-inflammation effect of ABT-702 was supported by the TNF-α release blocking effect of A 2A AR antagonist in AGA-treated microglial cells. Significance These results suggest a role for AK in regulating adenosine receptor signaling in the retina.

Övriga projekt. 889. 702. Totalt.

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742 34 ÖSTHAMMAR. 0173-211 10. 1. Uppdatera uppgifter. ABT Bolagen AB c/o c/o Assistancekåren Berglundavägen 20 702 36 ÖREBRO. 019-147700. 10.

ABT 702 was also highly selective for AK inhibition as compared to other sites of ADO action including ADA, ADO receptors, and ADO transport sites.